Age-Related Total Gray Matter and White Matter Changes in Normal Adult Brain. Part I: Volumetric MR Imaging Analysis
Yulin Gea,
Robert I. Grossmana,
James S. Babbc,
Marcie L. Rabina,
Lois J. Mannona and
Dennis L. Kolsonb
a Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA
b Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA
c Department of Biostatistics, Fox Chase Cancer Center, Philadelphia, PA
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FIG 1. Segmented images from one section based on various MR images. The normalized volume measure is tissue volume (E or F) relative to the total intracranial volume (C).
A, Original dual-echo FSE proton density-weighted image.
B, T2-weighted MR image.
C, Total intracranial volume image.
D, CSF volume image.
E, GM volume image.
F, WM volume image.
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FIG 2. Regression analysis of fractional brain tissue volume estimates on age in 54 healthy adult subjects. Linear and weighted constrained quadratic models are presented; these indicate the age-related volume estimates throughout adulthood in normal brains.
A, %GM.
B, %WM.
C, GM/WM ratio.
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FIG 3. Regression analysis of fractional volume estimates on age in the brain tissues of healthy male and female subjects. Despite the lack of statistical power, some trends seem to be present.
A, Faster decrease in %GM in male subjects with aging (solid predicted line).
B, Generally higher %WM volume in female subjects (dotted predicted line).
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