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AJNR - American Journal of Neuroradiology

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Age-Related Total Gray Matter and White Matter Changes in Normal Adult Brain. Part II: Quantitative Magnetization Transfer Ratio Histogram Analysis

Yulin Ge^a, Robert I. Grossman^a, James S. Babb^c, Marcie L. Rabin^a, Lois J. Mannon^a and Dennis L. Kolson^b

^a Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA
^b Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA
^c Department of Biostatistics, Fox Chase Cancer Center, Philadelphia, PA

View larger version (115K): [in a new window]   FIG 1. Image data sets for calculating GM and WM MTRs by using the image-processing program. A and B, Dual-echo FSE proton density–weighted (A) and T2-weighted (B) images. C and D, Images obtained with the MT saturation sequence off (C) and on (D). E and F, Segmented volume image of GM (E) and WM (F) were generated from original proton density–and T2-weighted images.

View larger version (29K): [in a new window]   FIG 2. Simplified image analysis schematic for the MTR histogram construction.

View larger version (14K): [in a new window]   FIG 3. MTR histograms in younger (< 50 years) and older ( 50 years) groups in healthy adults. The normalized peak height was significantly lower in the older group in both tissues. Compared with WM, GM has smaller MTR values. A, Global GM. B, Global WM.

View larger version (13K): [in a new window]   FIG 4. Regression analysis of MTR means in all subjects with age. Note that both GM and WM MTR means show a quadratic pattern with age during human adult life. A, GM. B, WM.