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AJNR - American Journal of Neuroradiology

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Proton Chemical Shift Imaging in Pick Complex

Osamu Kizu^a, Kei Yamada^a and Tsunehiko Nishimura^a

^a From the Department of Radiology, Kyoto Prefectural University of Medicine

View larger version (43K): [in a new window]   FIG 1. Proton MR spectra from bilateral basal ganglia and perisylvian regions in a case of FTD. Arrows indicate the chosen voxels. A T1-weighted MR image with VOI, which is outlined by a box, can be seen as a reference. In this case, NAA at 2.0 ppm was observed in the left basal ganglia.

View larger version (47K): [in a new window]   FIG 2. Proton MR spectra from the bilateral basal ganglia and perisylvian regions in a case of CBD. Arrows indicate the chosen voxels. In this case, reduced NAA was observed in bilateral basal ganglia.

View larger version (45K): [in a new window]   FIG 3. Proton MR spectra from bilateral basal ganglia and perisylvian regions in a case of PPA. Arrows indicate the chosen voxels. Note reduced NAA in the left basal ganglia and left perisylvian region.

View larger version (25K): [in a new window]   FIG 4. Box plots of peak ratios (NAA/Cho, NAA/Cr, and Cho/Cr) among controls subjects and patients with PC, FTD, CBD, and PPA. The box stretches from the lower hinge (defined as the 25th percentile) to the upper hinge (defined as the 75th percentile), and the median is shown as a line across the box. Outside the box, 10th and 90th percentile lines are shown. A statistically significant decrease in NAA/Cho was found in the right basal ganglia among patients with PC (P = .028). NAA/Cr ratio from the right perisylvian regions in patients with PPA and CBD were lower than that in control subjects (P = .025 and P = .025, respectively). No statistically significant difference in peak ratio was found in the left perisylvian regions or the left basal ganglia.