Metachromatic Leukodystrophy: Diffusion MR Imaging Findings
R. Nuri Senera
a Department of Radiology, Ege University Hospital, Bornova, Izmir, Turkey
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FIG 1. Images obtained at initial examination, performed when the patient was 10 months old.
A, T2-weighted image reveals hyperintense changes in the deep white matter and atrophy.
B, A b = 1000 mm2/s (heavily diffusion-weighted) image from an echo-planar trace sequence reveals hyperintense changes similar to those of cytotoxic edema.
C, Corresponding ADC map reveals a low signal intensity and low ADC value (0.55 x 10-3 mm2/s) in the deep white matter compared with the peripheral regions of the parenchyma, including peripheral white matter and the cortex (0.95 x 10-3 mm2/s).
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FIG 2. Images obtained during follow-up, when the patient was 16 months old.
A, A b = 1000 mm2/s (heavily diffusion-weighted) image from echo-planar trace sequence reveals same hyperintense lesions.
B, Gradient-echo diffusion sequence (reverse fast imaging in steady-state precession) reveals high signal intensity and high pixel values (165) in the deep white matter, compared with the peripheral regions of the parenchyma (99).
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AJNR - American Journal of Neuroradiology