Fetal Cytomegalovirus Infection of the Brain: The Spectrum of Sonographic Findings
Gustavo Malingera,b,
Dorit Leva,c,
Neriman Zahalkaa,b,
Zahi Ben Aroiaa,b,
Nathan Watemberga,d,
Deborah Kidrone,
Liat Ben Siraf and
Tally Lerman-Sagiea,d
a Fetal Neurology Clinic, Edith Wolfson Medical Center, Holon, Israel
b Prenatal Diagnosis Unit, Department of Obstetrics and Gynecology, Edith Wolfson Medical Center, Holon, Israel
c Institute of Medical Genetics, Edith Wolfson Medical Center, Holon, Israel
d Pediatric Neurology Unit, Edith Wolfson Medical Center, Holon, Israel
e Department of Pathology, Sapir Medical Center, Kfar Saba, Israel
f Pediatric Radiology Unit, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
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FIG 1. Fetus 1.
Parasagittal transvaginal sonogram of the fetal brain at 25 weeks’ gestation shows abnormal periventricular hyperechogenicity (arrows) and intraventricular adhesion (arrowhead).
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FIG 2. Fetus 3.
A, Parasagittal transvaginal sonogram of the fetal brain at 22 weeks’ gestation shows abnormal periventricular echogenicity with cystic formation (arrow) and striatal artery vasculopathy (arrowhead). Observe the presence of ventriculomegaly.
B, Sagittal transvaginal sonogram shows large cisterna magna (cm) and 4th ventricle (v), with hypoplastic vermis (arrow).
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FIG 3. Fetus 7.
A, Parasagittal transvaginal sonogram of the fetal brain at 37 weeks’ gestation shows periventricular tissue protruding through an undefined ependyma (arrow).
B, Parasagittal sonogram shows a periventricular cyst (p) protruding into a large lateral ventricle.
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FIG 4. Fetus 5.
Parasagittal transvaginal sonogram of the fetal brain at 31 weeks’ gestation shows abnormal underdeveloped pre- and postcentral gyri and calcifications (arrows).
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FIG 5. Fetus 2.
A, Coronal transvaginal sonogram of the fetal brain at 29 weeks’ gestation shows parenchymal foci of increased echogenicity consistent with calcifications (solid arrows) and abnormal sulcation (open arrows).
B, Sagittal transvaginal sonogram shows hypoplastic, blurred corpus callosum. The genu of the corpus callosum is not observed (open arrows), the splenium is thin (solid arrow). csp indicates cavum septum pellucidum.
C,Sagittal transvaginal sonogram shows cerebellar echogenic foci (arrow).
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