Language Processing during Natural Sleep in a 6-Year-Old Boy, as Assessed with Functional MR Imaging
Marko Wilkea,b,
Scott K. Hollanda and
William S. Ball, Jra
a Imaging Research Center, Cincinnati Children’s Hospital Medical Center, OH
b Department of Psychiatry, Cincinnati Children’s Hospital Medical Center, OH
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FIG 1. Contrast-enhanced T1-weighted image demonstrates the enchancing lesion in a 6-year-old boy with complex partial seizures in the left temporal lobe.
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FIG 2. Functional MR data obtained in subjects who were performing a story-listening task.
A, Reference data from four healthy 6-year-old boys obtained while they were listening to stories (active condition) or tones (control condition). Note the variability in the activation patterns.
B, Imaging data from our patient who performed the same task while awake (top) and in the sleeping state (bottom). Cross-correlation r=0.375, cluster size=5. Note that, at the same analysis threshold, stronger activation is shown in the sleep study
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FIG 3. Functional MR data obtained while patient was asleep.
A, Activation patterns observed during the sleeping study show activation in the expressive (top) and receptive (bottom) language areas.
B, Pixel intensity and time courses correlated with the reference function. Note the difference in responses between the expressive (top) and receptive (bottom) areas during the first three blocks. This finding suggests a regionally different response to the auditory stimulus.
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