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AJNR - American Journal of Neuroradiology

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Whole Brain Imaging of HIV-Infected Patients: Quantitative Analysis of Magnetization Transfer Ratio Histogram and Fractional Brain Volume

Yulin Ge^a, Dennis L. Kolson^b, James S. Babb^a, Lois J. Mannon^a and Robert I. Grossman^a

^a Department of Radiology, New York University School of Medicine, New York, NY
^b Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA

View larger version (140K): [in a new window]   FIG 1. T2-weighted MR images (left), segmented brain parenchyma volume images (middle), and CSF volume images (right). The loss of brain parenchyma, as reflected by the enlargement of ventricles and sulci, was most apparent in the symptomatic patient. A, Normal control participant. B, Asymptomatic patient. C, Symptomatic patient.

View larger version (18K): [in a new window]   FIG 2. MTR histograms from asymptomatic and symptomatic patients with HIV and from normal control participants. Histograms from two patient groups were shifted to the left toward the lower MTR values. Normalized peak height was generally lower for symptomatic patients compared with the other two groups.