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AJNR - American Journal of Neuroradiology

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Gray Matter N-Acetyl Aspartate Deficits in Secondary Progressive but Not Relapsing-Remitting Multiple Sclerosis

Elfar Adalsteinsson^a, Annette Langer-Gould^b, Ronald J. Homer^a, Archana Rao^a, Edith V. Sullivan^c, Christiane Abbehusen Lima^a, Adolf Pfefferbaum^c,d and Scott W. Atlas^a

^a Department of Radiology, Stanford University School of Medicine, Stanford, CA
^b Department of Neurology, Stanford University School of Medicine, Stanford, CA
^c Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA
^d Neuroscience Program, SRI International, Menlo Park, CA

View larger version (39K): [in a new window]   FIG 1. Example of nine axial sections used in quantification of metabolites (NAA images, top) and lesions (FLAIR images, bottom).

View larger version (9K): [in a new window]   FIG 2. Group means and individual data of NAA concentrations in GM and WM in controls, RRMS, and SPMS.