Tanycytomas: A Newly Characterized Hypothalamic-Suprasellar and Ventricular Tumor
K.A. Liebermana,
J.J. Wasenkoa,
R. Schelperb,
A. Swarnkara,
J.K. Changa and
G.S. Rodziewiczc
a Department of Neuroradiology, State University of New York Upstate Medical University, Syracuse, New York
b Department of Neuropathology, State University of New York Upstate Medical University, Syracuse, New York
c Department of Neurosurgery, State University of New York Upstate Medical University, Syracuse, New York
View larger version (110K):
[in a new window]
|
FIG 1. Case 1. This 2.5-year-old female patient was unresponsive.
A and B, Axial T1-weighted contrast-enhanced images (350/12/2 [TR/TE/NEX]) show a necrotic enhancing suprasellar mass encasing the distal internal carotid arteries.
C, Composite image.
D, Maximum intensity projection image from 3D time-of-flight MR angiogram, No blood flow is visualized beyond the supraclinoid portions of internal carotid arteries.
| |
View larger version (219K):
[in a new window]
|
FIG 2. Case 2. Two-year-old male patient with diplopia and a decrease in left eye vision.
A, Axial T2-weighted image (3200/84/1) shows a hyperintense suprasellar mass encasing the anterior portion of the circle of Willis.
B, Axial T1-weighted image (433/16/2) shows a hypointense suprasellar mass encasing the circle of Willis.
C, Contrast-enhanced sagittal T1-weighted image (650/14/2) shows a solid-cystic enhancing hypothalamic-suprasellar mass.
D, Contrast-enhanced coronal view T1-weighted image (400/16/2).
E, Photomicrograph of hematoxylin and eosin-stained normal tanycytes (arrowheads) radiating to a blood vessel (arrows) in area postrema.
F, Photomicrograph of hematoxylin and eosin-stained neoplastic cells (arrowheads) radiating to blood vessel (arrows) in tanycytoma specimen.
G, Photomicrograph of electron microscopy of tumor specimen reveals tanycytes with long synaptic processes (red arrow) and synaptoid complexes (yellow arrow).
| |
View larger version (83K):
[in a new window]
|
FIG 3. Case 4. This 26-year-old female patient presented with galactorrhea and hypothyroidism.
A, Sagittal view T1-weighted image (433/8/2) shows a hypointense hypothalamic mass.
B, Axial view T2-weighted image (3200/88/2) shows a hyperintense hypothalamic mass with suprasellar extension.
C, Coronal view T1-weighted contrast-enhanced image (400/9/2) shows a homogeneously enhancing hypothalamic-suprasellar mass.
D, Photomicrograph of tumor specimen stained with glial fibrillary acidic protein shows positive brown-stained glial processes (arrowheads) radiating to blood vessel (arrows).
E, Photomicrograph of tumor specimen stained with synaptophysin shows positive brown-stained glial processes (arrowheads) radiating to blood vessel (arrows).
| |
