Advanced

AJNR - American Journal of Neuroradiology

This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Quigley, M. Articles by Meyerand, M. E. Search for Related Content PubMed PubMed Citation Articles by Quigley, M. Articles by Meyerand, M. E.

Role of the Corpus Callosum in Functional Connectivity

Michelle Quigley^a, Dietmar Cordes^a, Pat Turski^b, Chad Moritz^a, Victor Haughton^b, Raj Seth^c and M. Elizabeth Meyerand^a

^a Department of Medical Physics, University of Wisconsin, Madison
^b Department of Radiology, University of Wisconsin, Madison
^c Department of Neurology, University of Wisconsin, Madison

View larger version (130K): [in a new window]   FIG 1. Functional connectivity and activation in the sensorimotor cortex of the three patients with agenesis of the corpus callosum. Left, Image displays the activation data from sensorimotor cortex identified by bilateral finger tapping. Middle, Image displays the functional connectivity data as the voxels functionally connected with a seed voxel cluster were chosen in the right sensorimotor cortex. Right, Image displays the functional connectivity data as voxels functionally connected to a seed voxel were selected in the left sensorimotor cortex. Note that with one exception (middle image in C), all functionally connected voxels are in the hemisphere ipsilateral to that of the seed voxel. A, Patient A. B, Patient B. C, Patient C.

View larger version (141K): [in a new window]   FIG 2. Functional connectivity in the auditory cortex of the three patients with agenesis of the corpus callosum. Left, Image displays the activation data from the auditory cortex during a text-listening task. Middle, Image displays the functional connectivity data as the voxels functionally connected to a seed voxel cluster were chosen in the right auditory cortex. Right, Image displays the functional connectivity data as voxels functionally connected to a seed voxel were selected in the left auditory cortex. A, Patient A. B, Patient B. C, Patient C

View larger version (79K): [in a new window]   FIG 3. Functional connectivity maps from healthy control subjects with an intact corpus callosum. Notice the bilateral connectivity in both maps in contrast to the agenesis data shown in Figures 1 and 2. A, Seed voxel chosen from the right auditory cortex. B, Seed voxel chosen from the right sensorimotor cortex.