Marchiafava-Bignami Disease: Longitudinal MR Imaging and MR Spectroscopy Study
Anna Gambinia,
Andrea Falinia,
Lucia Moiolab,
Giancarlo Comia,b and
Giuseppe Scottia
a Neuroradiology Department, Scientific Institute Ospedale San Raffaele, University Vita-Salute San Raffaele, Milan, Italy
b Neurology Department, Scientific Institute Ospedale San Raffaele, University Vita-Salute San Raffaele, Milan, Italy
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FIG 1. MR images obtained 1 month after the onset of symptoms.
A, Sagittal T2-weighted MR image (2600/14, 85/2 [TR/TE, second TE/NEX]). Hyperintensity of the entire corpus callosum is present.
B, Coronal inversion recovery image (9520/60/2 [TR/TI/NEX]). The corpus callosum appears hypointense, with sparing of fibers in the superficial and central portion.
C, Axial fluid-attenuated inversion recovery image (9999/105/1). Bilateral foci of hyperintensity in the white matter of the centrum semiovale.
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FIG 2. MR images obtained 4 months after the onset of symptoms (A–C) and 11 months after onset (D and E).
A, Sagittal T2-weighted MR image (2600/14, 85/2). Slight reduction of abnormal signal intensity can be seen in the genu and anterior half of the body of the corpus callosum, which appears thinned.
B, Axial T2-weighted MR image (2600/14, 85/2).
C, Axial fluid-attenuated inversion recovery image (9999/105/1) shows the disappearance of foci of hyperintensity in the centrum semiovale.
D, Sagittal T2-weighted image (2600/14, 85/2). Slight hyperintensity persists in the splenium; the corpus callosum is moderately atrophic.
E, Axial T2-weighted image (2600/14, 85/2) shows slight hyperintensity of the splenium.
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FIG 3. Evolution with time of metabolic profile of the splenium of the corpus callosum. Progressive normalization of the Cho/Cr ratio is initially slightly increased; progressive reduction of the NAA/Cr ratio, with a minimum at 4 months and a partial recovery at 11 months; presence of Lac at 1 and 2 months replaced by Lip at 4 months.
A, Metabolic profile at 1 month.
B, Metabolic profile at 2 months.
C, Metabolic profile at 4 months.
D, Metabolic profile at 11 months.
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