Reliable Callosal Measurement: Population Normative Data Confirm Sex-Related Differences
Tejal N. Mitchella,b,
Samantha L. Freea,b,
Martin Merschhemkea,c,
Louis Lemieuxa,b,
Sanjay M. Sisodiyaa,b and
Simon D. Shorvona
a Department of Clinical and Experimental Epilepsy, University Department of Clinical Neurology, Institute of Neurology, University College London, Queen Square, London, UK
b National Society for Epilepsy, Chalfont St Peter, Buckinghamshire, UK
c Epilepsie-Zentrum Berlin am Königin-Elisabeth-Krankenhaus, Germany
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FIG 1. Definition of the midsagittal plane. For the coronal images: x indicates left to right; y, posterior to anterior; and z, inferior to superior.
A, Coronal image through the AC (left), axial image through the PC (middle), and sagittal image of the AC-PC line before the first rotation (right).
B, AC-PC line orthogonal to the image cuboid.
C, Coronal image demonstrating the AC-IF line.
D, Sagittal image through the midsagittal plane after the final rotation.
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FIG 2. Scatterplots.
A, Distribution of CCA and cerebral volume (solid squares indicate men, open circles indicate women). Regression analyses results: men, R2 = 0.10 and P = .004; women, R2 = 0.14 and P = .039.
B, Lack of correlation of the CCA-cerebral volume ratio with age (solid squares indicate men, open circles indicate women)
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FIG 3. Application of the method to subject data with minimal head tilt and rotation within the unit.
A and B, Coronal and axial images through the AC. The midsagittal plane used to reformat the midsagittal image by using the criteria of Coffman (25) is seen in A.
C, Midsagittal plane, reformatted image. CCA is 5.53 cm2.
D and E, AC, PC, and IF after reorientation by using protocol described in Methods. Coronal (D) and axial (E) images.
F, Midsagittal reformatted image after reorientation. CCA = 6 .93 cm2.
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FIG 4. Application of the method to the data; on visual inspection, they appear to be in an optimal orientation.
A–C, Original data. Coronal (A) and axial (B) images through the AC and midsagittal image (C) reformatted by using the criteria of Coffman et al (25). CCA = 5 .65 cm2
D–F, Coronal (D), axial (E), and midsagittal (F) images after reorientation and subsequent reformatting of the midsagittal plane by using our method. CCA = 6 .57 cm2.
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