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Gabapentin Therapy for Amyotrophic Lateral Sclerosis: Lack of Improvement in Neuronal Integrity Shown by MR Spectroscopy

Sanjay Kalraa,b, Neil R. Cashmanc, Zografos Caramanosb, Angela Gengea and Douglas L. Arnolda,b

a Department of Neurology and Neurosurgery, McGill University (S.K., A.G., D.L.A.)
b Magnetic Resonance Spectroscopy Unit, Montreal Neurological Institute and Hospital (S.K., Z.C., D.L.A.), Quebec
c Centre for Research in Neurodegenerative Diseases, University of Toronto, Ontario (N.R.C.), Canada



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  		FIG 1. Axial T1-weighted MR image with a superimposed phase-encoding grid and volumes of interest. Voxels selected for the five cortical-subcortical regions are outlined: 1 indicates the precentral gyrus; 2, the postcentral gyrus; 3, the superior parietal lobule; 4, the supplementary motor area; and 5, the premotor cortex.





Copyright © 2009 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X