Correlations of Hippocampal Atrophy and Focal Low-Frequency Magnetic Activity in Alzheimer Disease: Volumetric MR Imaging-Magnetoencephalographic Study
Alberto Fernándeza,
Juan Arrazolab,
Fernando Maestúa,
Carlos Amoa,
Pedro Gil-Gregorioc,
Christian Wienbruchd and
Tomás Ortiza
a Center for Magnetoencephalography Dr Pérez Modrego, Universidad Complutense de Madrid (A.F., F.M., C.A., T.O.)
b Department of Neuroradiology (J.A.) Hospital Universitario San Carlos, Madrid, Spain
c Department of Geriatrics (P.G.-G.), Hospital Universitario San Carlos, Madrid, Spain
d University of Konstanz and Center for Psychiatry, Reichenau, Konstanz, Germany (C.W.)
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FIG 1. T1-weighted MR images display the relative global cerebral volume in a patient with AD in axial and sagittal views. Green represents the final region where the volume calculation was performed.
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FIG 2. T1-weighted MR images display the relative hippocampal volume in a patient with AD in the axial and sagittal planes. Green represents the final region where the volume calculation was performed.
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FIG 3. Histogram representing the results of the discriminant analysis for the Alzheimer group: x axis reflects canonical scores, and y axis reflects the number of subjects who obtained every canonical score. Those with canonical scores below zero were classified as belonging to the AD group; three controls were incorrectly classified within the AD group.
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FIG 4. Histogram representing the results of the discriminant analysis for the control group: x axis reflects canonical scores, and y axis reflects the number of subjects who obtained every canonical score. Those with canonical scores greater than zero were classified as controls; one AD patient was incorrectly classified as belonging to the control group.
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