Lack of Sex Effect on Brain Activity during a Visuomotor Response Task: Functional MR Imaging Study
Nina Mikhelashvili-Browner1,
David M. Yousem1,
Colin Wub,
Michael A. Kraut1,
Christina L. Vaughana,
Kader Karli Oguz1,c and
Vince D. Calhouna
1 Johns Hopkins Hospital, the Russell H. Morgan Department of Radiology and Radiological Sciences, Division of Neuroradiology (N.M.-B., D.Y.M., M.K., K.K.O.)
a Division of Psychiatric Neuro-Imaging (C.L.V., V.D.C.), Baltimore, MD
b Office of Biostatistics Research, DECA, National Heart, Lung and Blood Institute (C.W.), Bethesda, MD
c Department of Radiology, Hacettepe University, School of Medicine, Turkey (K.K.O.)
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FIG 1. Motor activation during the visuomotor response task. Activation was superimposed onto normalized T1-weighted MR images by using SPM99. All regions displayed showed significant activation (P < .001 uncorrected for multiple comparisons). Top row, Individual SPM99 maps of a representative male subject show contralateral and ipsilateral M1 activation. Bottom row, Individual SPM99 maps of a representative female subject show similar degrees of left M1 and SMA activation.
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FIG 2. Visual activation during visuomotor response task. Activation was superimposed onto normalized T1-weighted MR images by using SPM99. Significant medial occipital cortex activation (P < .001 uncorrected for multiple comparisons) is demonstrated in a representative. Top, Image in male subject. Bottom, Image in female subject.
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FIG 3. Surface-rendered activation in a representative female subject. Activation was superimposed on a T1-weighted by using the Montreal Neurologic Institute template provided by SPM99. All regions displayed showed significant activation (P < .001 uncorrected for multiple comparisons).
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FIG 4. Surface-rendered activation in a representative male subject. Activation was superimposed on a T1-weighted by using the Montreal Neurologic Institute template provided by SPM99. All regions displayed showed significant activation (P < .001 uncorrected for multiple comparisons).
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FIG 5. Random effects SPM99 of male versus female brain activation during visuomotor response task. Two-way t test (T = 3 .47, P < .001 uncorrected for multiple comparisons) shows no difference in brain activation at any defined specified site: RV, LV, LM1, LSMA, and LACA. However, men had a larger volume of activation in right inferior parietal lobule, right insula, and left thalamus.
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