AJDRAJNR - American Journal of Neuroradiology

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Quantification of Brain Damage in Cerebrotendinous Xanthomatosis with Magnetization Transfer MR Imaging

Matilde Inglesea, Nicola DeStefanoc, Elisabetta Pagania, Maria T. Dottic, Giancarlo Comib, Antonio Federicoc and Massimo Filippia

a Neuroimaging Research Unit, Department of Neuroscience, Milan, Italy
b Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
c Neurometabolic Unit, Institute of Neurological Sciences, University of Siena, Siena, Italy



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FIG 1. A–C, MT ratio (MTR) histograms from patients with CTX (black line) and healthy volunteers (gray line) for whole brain (WB) (A), brain NAWM (B), and brain NAGM (C).



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FIG 2. Scatterplot of the correlation between the EDSS score and composite whole-brain (WB) MT ratio (MTR) histogram score in the nine patients with CTX (r =0.77).