Quantification of Brain Damage in Cerebrotendinous Xanthomatosis with Magnetization Transfer MR Imaging
Matilde Inglesea,
Nicola DeStefanoc,
Elisabetta Pagania,
Maria T. Dottic,
Giancarlo Comib,
Antonio Federicoc and
Massimo Filippia
a Neuroimaging Research Unit, Department of Neuroscience, Milan, Italy
b Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
c Neurometabolic Unit, Institute of Neurological Sciences, University of Siena, Siena, Italy

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FIG 1. AC, MT ratio (MTR) histograms from patients with CTX (black line) and healthy volunteers (gray line) for whole brain (WB) (A), brain NAWM (B), and brain NAGM (C).
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FIG 2. Scatterplot of the correlation between the EDSS score and composite whole-brain (WB) MT ratio (MTR) histogram score in the nine patients with CTX (r =0.77).
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