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Differentiation of Toxoplasmosis and Lymphoma in AIDS Patients by Using Apparent Diffusion Coefficients

Daniel L. A. Camachoa, J. Keith Smitha and Mauricio Castilloa

a From the Department of Radiology, University of North Carolina, Chapel Hill



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  		FIG 1. ADC ratios in toxoplasmosis and lymphoma lesions. Column heights and error bars represent the mean and SD, respectively. ADC ratios in the toxoplasmosis lesions are significantly greater than those in the lymphoma lesions.



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  		FIG 2. Axial images in an AIDS patient with toxoplasmosis.

A, Axial T1-weighted gadolinium-enhanced MR image. The lesion in the right basal ganglia has an irregular, enhancing rim.

B, DW image (b = 1000 s/mm2). The core of the lesion demonstrates unrestricted diffusion.

C, ADC map of a toxoplasmosis lesion in the right basal ganglia. The outline indicates the ROI within the lesion used for ADC computation. The core of the lesion has a mean ADC that is increased relative to that in normal white matter (ADC ratio, 2.23).



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  		FIG 3. Axial images in an AIDS patient with lymphoma.

A, Axial T1-weighted gadolinium-enhanced MR image. A lesion with an enhancing rim is present in the left frontal lobe.

B, DW image (b = 1000 s/mm2). The signal intensity of the core of the lesion is similar to that of uninvolved white matter.

C, ADC map of a lymphoma lesion in the left frontal lobe. The outline indicates the ROI within the lesion used for ADC computation. The core of the lesion has a mean ADC that is similar to that of normal white matter (ADC ratio, 1.25).





Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X