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AJNR - American Journal of Neuroradiology

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Coefficient D_av Is More Sensitive Than Fractional Anisotropy in Monitoring Progression of Irreversible Tissue Damage in Focal Nonactive Multiple Sclerosis Lesions

Alessandro Castriota-Scanderbeg^a, Fabrizio Fasano^b, Gisela Hagberg^b, Ugo Nocentini^c, Massimo Filippi^d and Carlo Caltagirone^c

^a Department of Radiology, Scientific Institute Fondazione S. Lucia, Rome
^b the Laboratory of Neuroimaging, Scientific Institute Fondazione S. Lucia, Rome
^c the Neurological Rehabilitation Unit, Scientific Institute Fondazione S. Lucia and Università "Tor Vergata," Rome
^d the Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute Ospedale San Raffaele, Milan, Italy

View larger version (146K): [in a new window]   FIG 1. Three examples of MS lesions (arrows) with different T1 appearance. Top, isointense lesion (FA=0.30 ± 0.06, coefficient Dav=1.10 ± 0.07 x 10-3 mm2/s); middle, mildly hypointense lesion (FA=0.27 ± 0.05, coefficient Dav=1.24 ± 0.06 x 10-3 mm2/s); bottom, severely hypointense lesion (FA=0.19 ± 0.04, coefficient Dav = 1.76 ± 0.07 x 10-3 mm2/s). For each row, from left to right: axial view fast spin-echo T2-weighted image, spin-echo T1-weighted image, coefficient Dav map, and FA map.

View larger version (21K): [in a new window]   FIG 2. Scatter plots for the 76 lesions studied. A, Coefficient Dav versus SIlesion/SICSF ratio. Significant inverse correlation was shown. B, FA versus SIlesion/SICSF ratio. No correlation was shown.