AJDRAJNR - American Journal of Neuroradiology

This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Castriota-Scanderbeg, A.
Right arrow Articles by Caltagirone, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Castriota-Scanderbeg, A.
Right arrow Articles by Caltagirone, C.

Coefficient Dav Is More Sensitive Than Fractional Anisotropy in Monitoring Progression of Irreversible Tissue Damage in Focal Nonactive Multiple Sclerosis Lesions

Alessandro Castriota-Scanderbega, Fabrizio Fasanob, Gisela Hagbergb, Ugo Nocentinic, Massimo Filippid and Carlo Caltagironec

a Department of Radiology, Scientific Institute Fondazione S. Lucia, Rome
b the Laboratory of Neuroimaging, Scientific Institute Fondazione S. Lucia, Rome
c the Neurological Rehabilitation Unit, Scientific Institute Fondazione S. Lucia and Università "Tor Vergata," Rome
d the Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute Ospedale San Raffaele, Milan, Italy



View larger version (146K):

[in a new window]
  		FIG 1. Three examples of MS lesions (arrows) with different T1 appearance. Top, isointense lesion (FA=0.30 ± 0.06, coefficient Dav=1.10 ± 0.07 x 10-3 mm2/s); middle, mildly hypointense lesion (FA=0.27 ± 0.05, coefficient Dav=1.24 ± 0.06 x 10-3 mm2/s); bottom, severely hypointense lesion (FA=0.19 ± 0.04, coefficient Dav = 1.76 ± 0.07 x 10-3 mm2/s). For each row, from left to right: axial view fast spin-echo T2-weighted image, spin-echo T1-weighted image, coefficient Dav map, and FA map.



View larger version (21K):

[in a new window]
  		FIG 2. Scatter plots for the 76 lesions studied.

A, Coefficient Dav versus SIlesion/SICSF ratio. Significant inverse correlation was shown.

B, FA versus SIlesion/SICSF ratio. No correlation was shown.





Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X