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Apparent Diffusion Coefficient Determination in Normal Fetal Brain: A Prenatal MR Imaging Study

Andrea Righinia, Elena Bianchinia, Cecilia Parazzinia, Patrizia Gementib, Luca Ramenghic, Cristina Baldolid, Umberto Nicolinib, Fabio Moscac and Fabio Triulzia

a Department of Neuroradiology, Istituti Clinici di Perfezionamento, Milan, Italy
b Department of Gynecology, Istituti Clinici di Perfezionamento, Milan, Italy
c Department of Neonatology, Istituti Clinici di Perfezionamento, Milan, Italy
d Department of Neuroradiology, Universita’ Salute e Vita - IRCCS San Raffaele, Milan, Italy



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FIG 1. Representative case (fetus 10 in Table). A, T2-weighted echo-planar image (b = 0 s/mm2), B, corresponding DW image, and C, resultant trace ADC map illustrate typical ROIs (circles in A and C) traced on an axial section at the basal ganglia level.



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FIG 2. Graph shows the mean ADC values (bars indicate 2 SDs) for frontal and occipital white matter, basal ganglia, and CSF ROIs. The mean ADC of basal ganglia is significantly lower than that of white matter ROIs. * indicates P < .0001 (paired t test).



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FIG 3. Graphs show the correlation between ADC values for the ROIs traced and gestational age. A significant negative correlation was present only for the basal ganglia ROI.

A, Basal ganglia: Y = 2.222 - 0.024X; R2 = 0.471; P = .0096.

B, Frontal white matter: Y = 2.394 - 0.015X; R2 = 0.182; P = .1457.

C, Occipital white matter: Y = 2.14 - 0.007X; R2 = 0.028; P = .5654.