Apparent Diffusion Coefficient Determination in Normal Fetal Brain: A Prenatal MR Imaging Study
Andrea Righinia,
Elena Bianchinia,
Cecilia Parazzinia,
Patrizia Gementib,
Luca Ramenghic,
Cristina Baldolid,
Umberto Nicolinib,
Fabio Moscac and
Fabio Triulzia
a Department of Neuroradiology, Istituti Clinici di Perfezionamento, Milan, Italy
b Department of Gynecology, Istituti Clinici di Perfezionamento, Milan, Italy
c Department of Neonatology, Istituti Clinici di Perfezionamento, Milan, Italy
d Department of Neuroradiology, Universita Salute e Vita - IRCCS San Raffaele, Milan, Italy

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FIG 1. Representative case (fetus 10 in Table). A, T2-weighted echo-planar image (b = 0 s/mm2), B, corresponding DW image, and C, resultant trace ADC map illustrate typical ROIs (circles in A and C) traced on an axial section at the basal ganglia level.
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FIG 2. Graph shows the mean ADC values (bars indicate 2 SDs) for frontal and occipital white matter, basal ganglia, and CSF ROIs. The mean ADC of basal ganglia is significantly lower than that of white matter ROIs. * indicates P < .0001 (paired t test).
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FIG 3. Graphs show the correlation between ADC values for the ROIs traced and gestational age. A significant negative correlation was present only for the basal ganglia ROI.
A, Basal ganglia: Y = 2.222 - 0.024X; R2 = 0.471; P = .0096.
B, Frontal white matter: Y = 2.394 - 0.015X; R2 = 0.182; P = .1457.
C, Occipital white matter: Y = 2.14 - 0.007X; R2 = 0.028; P = .5654.
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