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AJNR - American Journal of Neuroradiology

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Diffusion Tensor Imaging in Cases of Adrenoleukodystrophy: Preliminary Experience as a Marker for Early Demyelination?

Jacques F. L. Schneider^a, Kamil A. Il’yasov^c, Eugen Boltshauser^b, Jürgen Hennig^a,b,c and Ernst Martin^a

^a Department of Neuroradiology and Magnetic Resonance Imaging, University Children’s Hospital, Zürich, Switzerland
^b Department of Neurology, University Children’s Hospital, Zürich, Switzerland
^c Department of Diagnostic Radiology, Section of Medical Physics, University Medical Center, Freiburg, Germany

View larger version (45K): [in a new window]   FIG 1. T2-weighed image (T2WI) and D' and FA maps of the blind patient (patient 2) shows confluent and symmetric abnormalities in the deep white matter of both occipital lobes. Regions of interest are shown on D' (-r) and FA (-l) maps (yellow outlines).

View larger version (56K): [in a new window]   FIG 2. T2-weighted images (T2WI) and D' and FA maps of patient 1. A, No signal intensity alteration is shown in the parietal white matter. B, No signal intensity alteration is shown in the occipital deep white matter. Regions of interest are shown on D' (-r) and FA (-l) maps (yellow outlines).

View larger version (41K): [in a new window]   FIG 3. T2-weighted image (T2WI) and D' and FA maps of patient 3. No signal intensity alteration is shown in the centrum semiovale. Regions of interest are shown on D' (-r) and FA (-l) maps (yellow outlines).