T1 Hyperintensity in the Pulvinar: Key Imaging Feature for Diagnosis of Fabry Disease
Jun-ichi Takanashia,
A. James Barkovicha,
William P. Dillona,
Elliott H. Sherrb,
Kimberly A. Hartc and
Seymour Packmanc
a the Neuroradiology Section, Department of Radiology, University of California, San Francisco, CA
b Department of Neurology, University of California, San Francisco, CA
c Division of Medical Genetics, Department of Pediatrics, University of California, San Francisco, CA
View larger version (104K):
[in a new window]
|
FIG 1. Patient 10.
A, Axial T1-weighted spin-echo image at the level of basal ganglia shows hyperintense lesions in the bilateral peripheral globus pallidus, lateral pulvinar (arrowhead), and medial occipital cortex.
B, Axial T2-weighted image spin-echo showing hypointensity in the bilateral globus pallidus (small arrowhead) and putamen (arrowhead).
C, Noncontrast axial CT scan reveals calcification in the bilateral globus pallidus and medial occipital cortex; however, no abnormal attenuation exists in the pulvinar.
D and E, Coronal gradient echo images show hypointensity in the putamen and substantia nigra (D, arrowhead) but normal SI in pulvinar (E).
| |
View larger version (88K):
[in a new window]
|
FIG 2. Patient 8.
A, T1-weighted spin-echo image at the level of basal ganglia shows hyperintensity in right globus pallidus and bilateral lateral pulvinar (arrowhead).
B, T2-weighted spin-echo image shows a small hyperintense foci in right frontal white matter and hypointensity in the bilateral lateral putamen (arrowhead) and pulvinar (small arrowhead).
| |
