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Peritumoral Diffusion Tensor Imaging of High-Grade Gliomas and Metastatic Brain Tumors

Stanley Lua, Daniel Ahna, Glyn Johnsona and Soonmee Chaa

a From the Department of Radiology, New York University Medical Center, NY



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  		FIG 1. Images in a patient with lung carcinoma.

A, Contrast-enhanced T1-weighted MR image demonstrates an enhancing mass adjacent to the central sulcus on the right side.

B, ROIs are placed within the hyperintense vasogenic edema on this T2-weighted MR image and within the corresponding contralateral white matter.

C, MD overlay map renders a mean MD of 0.908 x 10-3 mm2/s.

D, FA overlay map renders a mean FA of 0.114. The peritumoral DTI metrics are consistent with lung metastasis.



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  		FIG 2. Scatterplot of FA versus MD demonstrates lack of high correlation between the two variables (R = -0.70). The data in the metastasis group tend to lie within the higher range of MD, when compared with the data in the glioma group (P < .005). Along the FA axis, no such statistically significant discrepancy was observed.



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  		FIG 3. Images in a patient with glioblastoma multiforme.

A, Contrast-enhanced T1-weighted MR image demonstrates an enhancing mass in the left temporal lobe that is not clearly high-grade glioma nor clearly metastasis on this conventional MR image.

B, ROIs are placed within the hyperintense vasogenic edema on a T2-weighted MR image and within the corresponding contralateral white matter.

C, MD overlay map renders a mean MD of 0.603 x 10-3 mm2/s.

D, FA overlay map renders a mean FA of 0.301. The peritumoral DTI metrics are consistent with glioblastoma multiforme.



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  		FIG 4. Schematics illustrate the factors behind the comparable change in peritumoral FA.

A, Water content and axonal disorganization contributing to decreased FA.

B, Water content contributing to decreased FA





Copyright © 2009 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X