Advanced

AJNR - American Journal of Neuroradiology

This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Saraf-Lavi, E. Articles by Petito, C. K. Search for Related Content PubMed PubMed Citation Articles by Saraf-Lavi, E. Articles by Petito, C. K.

Proton MR Spectroscopy of Gliomatosis Cerebri: Case Report of Elevated Myoinositol with Normal Choline Levels

Efrat Saraf-Lavi^a, Brian C. Bowen^a, Pradip M. Pattany^a, Evelyn M.L. Sklar^a, James B. Murdoch^c and Carol K. Petito^b

^a Department of Radiology, University of Miami School of Medicine, Miami, FL
^b Department of Pathology, University of Miami School of Medicine, Miami, FL
^c Philips Medical Systems, Cleveland OH

View larger version (68K): [in a new window]   FIG 1. Spin-echo MR images. Axial view FLAIR image (left) shows extensive hyperintensity involving the left hemisphere white matter and basal ganglia, bilateral thalami, and splenium of corpus callosum, with mild mass effect. Comparison between unenhanced T1-weighted image (center) and contrast-enhanced T1-weighted image (right) reveals no appreciable enhancement.

View larger version (52K): [in a new window]   FIG 2. Single voxel spectroscopy. Localized STEAM (TE 20) spectra were acquired from the normal appearing right periatrial region (A1) and from the hyperintense left periatrial region (B1). PRESS (TE 135) spectra were acquired from the same locations (A2 and B2, respectively). The right and left STEAM spectra are displayed by using the same vertical scale factor, as are the right and left PRESS spectra.

View larger version (57K): [in a new window]   FIG 3. Spectroscopic imaging. Multi-voxel spectra (TE 135) from five different locations (marked by Xs) indicated on the axial FLAIR localizer. A, Right periatrial region. B, Left periatrial region. C, Right basal ganglia region. D, Left basal ganglia region. E, Left thalamus.

View larger version (138K): [in a new window]   FIG 4. Histopathology of left thalamic biopsy specimen. Moderately cellular infiltrating glioma (hematoxylin and eosin; original magnification, x400).