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Diffusion MR Imaging Changes Associated with Wilson Disease

R.N. Senera

a From the Department of Radiology, Ege University Hospital, Bornova, Izmir, 35100, Turkey



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  		FIG 1. Images from initial examination.

A, Proton density–weighted image reveals bilateral high signal intensity in the putamina and in the heads of the caudate nuclei.

B, Heavily diffusion-weighted (b = 1000 s/mm2) image reveals high signal intensity changes (restricted diffusion). This probably reflects accumulated copper.

C, Corresponding ADC map shows low ADC values, 0.49, 0.47, and 0.54 x 10-3 mm2/s, in the corresponding regions, compared with a normal ADC value from the parenchyma, 0.82 x 10-3 mm2/s.



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  		FIG 2. Images from second examination, performed 1.5 years later.

A, T2-weighted image reveals linear lesions in the putamina. Atrophy is noted.

B, Image with b = 1000 s/mm2 reveals low signal intensity in the putamina.

C, Corresponding ADC map reveals high ADC values, 2.08 and 6.01 x 10-3 mm2/s, in the putamina, compared with normal ADC value from the parenchyma, 0.85 x 10-3 mm2/s. The ADC value of CSF is 3.50 x 10-3 mm2/s.





Copyright © 2009 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X