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AJNR - American Journal of Neuroradiology

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Role of Subvoxel Free Fluid on Diffusion Parameters in Brain Tissue with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy and Its Correlation with Physical Disability: Histogram Analysis of Standard and Fluid-Attenuated MR Diffusion

Martin Dichgans^a, Benno Pütz^b, Daniel Boos^b and Dorothee P. Auer^b

^a Department of Neurology, Klinikum Grosshadern, Ludwig-Maximilians-Universität, AG NMR, Munich, Germany
^b Max-Planck Institute of Psychiatry, AG NMR, Munich, Germany

View larger version (128K): [in a new window]   FIG 1. Example of the segmentation procedure for macroscopic CSF and lesions distinct from lacunes. A, Axial view image of the b0 map from fluid-attenuated data. B, Mean diffusivity map from fluid-attenuated data obtained before segmentation. C, Mean diffusivity map from standard data obtained before segmentation. D, Mean diffusivity map from standard data obtained after segmentation for macroscopic CSF and lesions. The segmentation masks for macroscopic CSF and for lesions were obtained from the fluid-attenuated b0 maps (shown in A).

View larger version (19K): [in a new window]   FIG 2. Mean diffusivity histograms obtained from fluid-attenuated (upper panel) and standard (lower panel) data sets. Mean diffusivity histograms of whole brain (blue line), normal appearing brain tissue (green line), and lesions (red line) of patients with CADASIL and of control participants (black line). Standard histograms are broader with a pronounced asymmetry toward higher values of mean diffusivity.

View larger version (10K): [in a new window]   FIG 3. Scatterplot of the difference between average mean diffusivity from standard and fluid-suppressed histograms ( average mean diffusivity) for whole brain parenchyma versus physical disability (Rankin score).

View larger version (16K): [in a new window]   FIG 4. Scatterplot of average mean diffusivity from fluid-attenuated images of whole brain parenchyma versus the normalized volume of nonlacunar T2 lesions in patients with CADASIL.