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AJNR - American Journal of Neuroradiology

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MR Imaging and Spectroscopy of a Tuber Cinereum Hamartoma in a Patient with Growth Hormone Deficiency and Hypogonadotropic Hypogonadism

David D. Martin^a, Uwe Seeger^b, Michael B. Ranke^a and Wolfgang Grodd^b

^a Sections for Pediatric Endocrinology, University of Tübingen, Tübingen, Germany
^b Experimental Magnetic Resonance of the Central Nervous System, University of Tübingen, Tübingen, Germany

View larger version (168K): [in a new window]   FIG 1. MR image of hypothalamic hamartoma. Top row, pre- (A) and postcontrast (B) T1-weighted sagittal images T2-weighted coronal image (C). Bottom row, T2-weighted axial images at the level of the supracellular cistern (D) and the interpenduncular fossa (E). Panel F shows a diffusion-weighted image acquired at the level of the interpenduncular fossa. Note the lack of contrast enhancement of the hamartoma (B); signal intensity of the harmartoma is similar to that of cortical gray matter and the amygdala (C). Dorsal fusion with the mammilary body is also apparent (F).

View larger version (46K): [in a new window]   FIG 2. Short-TE spectra of the thalamus (left), hamartoma (middle), and amygdala (right). The locations of the respective volumes of interest are shown in the MR images above the spectra.