Technical Feasibility of Embolizing Aneurysms with Glue (N-butyl 2-cyanoacrylate): Experimental Study in Rabbits
Dae Chul Suha,
Kil Soo Kimc,
Soo Mee Lima,
Hai Bin Shid,
Choong Gon Choia,
Ho Kyu Leea and
Dong Man Seob
a Department of Radiology, University of Ulsan, College of Medicine, Seoul, Korea
b Department of Thoracic Surgery, University of Ulsan, College of Medicine, Seoul, Korea
c Department of Laboratory Animal Sciences, College of Medicine, Seoul National University, Korea
d Department of Radiology, First Affiliated Hospital of Nanjing Medical University, China
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FIG 1. Aneurysm 1. Complete glue embolization of aneurysm without a coil framework.
A, After obtaining this preembolization angiogram, 50% glue was injected for 2 minutes and 28 seconds under subtracted, real-time road-map fluoroscopy.
B and C, Frozen images of early (B) and late (C) phases show slow enlargement of the cast without fragmentation.
D and E, Angiograms obtained immediately after embolization (D) and at 2-month follow-up (E) show no residual lumen in the aneurysm and a patent carotid artery.
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FIG 2. Aneurysm 4. Partially embolized aneurysm without a coil framework.
A, After obtaining this preembolization angiogram, 40% glue was injected for 1 minute and 26 seconds under subtracted, real-time road-map fluoroscopy.
B–D, Frozen images of the early (B), middle (C), and late (D) phases show leakage of the cast along the wall.
E and F, Angiograms obtained immediately after embolization (E) and at 2-month follow-up (F) show persistent occlusion of the carotid artery.
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FIG 3. Aneurysm 16. Complete embolization with a coil framework.
A and B, After obtaining the preembolization angiogram (A), an 8 x 20-cm GDC was introduced into the aneurysm to make a coil framework (B) and 28% glue was injected for 2 minutes and 3 seconds under subtracted, real-time road-map fluoroscopy.
C and D, Frozen images of the early (C) and late (D) phases.
E and F, Angiorams obtained immediately after embolization (E) and at 2-month follow-up (F) reveal persistent obliteration of the aneurysm.
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FIG 4. Aneurysm 9. Partially embolized aneurysm after making a coil framework.
A–C, After obtaining a preembolization angiogram (A), an 8 x 20-cm GDC was introduced into the aneurysm to make a coil framework (B) and 50% glue was injected for 1 minute 35 seconds under subtracted, real-time road-map fluoroscopy (C). Glue could not be further injected probably because of the premature cast within the microcatheter.
D and E, Angiogram obtained immediately after embolization (D) shows a residual lumen within the aneurysm that appears smaller on the 2-month follow-up angiogram (E).
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FIG 5. Aneurysm 13. Glue spillage during injection after making a coil framework.
A–C, After obtaining a preembolization angiogram (A), a 5 x 15-cm GDC was introduced into the aneurysm to make a coil framework (B), and 33% glue was injected for 33 seconds under subtracted, real-time road-map fluoroscopy (C). Note the acute angle of the aneurysmal neck to the parent carotid artery.
D and E, Angiogram obtained immediately after embolization (D) shows a filling defect caused by spilled glue, which has been absorbed on the 2-month follow-up angiogram (E).
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