Whole-Brain N-Acetylaspartate Level and Cognitive Performance in HIV Infection
Sohil H. Patela,
Matilde Inglesea,
Guila Glosserb,
Dennis L. Kolsonb,
Robert I. Grossmana and
Oded Gonena
a Department of Radiology, New York University School of Medicine, New York, NY
b Department of Neurology, the University of Pennsylvania Medical Center, Philadelphia, PA
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FIG 1. Analysis of WBNAA concentration versus processing speed or ADC score.
A, WBNAA concentrations as a function of processing speed for each of the 15 HIV-infected patients. The solid line is the least-squares regression model used to predict WBNAA concentration (in millimoles) from the processing speed in HIV-infected patients, as follows: WBNAA = 12.38 - 0.2357 x processing speed. A higher processing speed score indicates increased impairment.
B, Box plots display the 25% (box bottom), median, 75% (box top) values and the ±95% (whiskers) range of the variation in WBNAA concentrations for HIV-infected patients in each of the ADC score categories and for their age- and sex-matched healthy subjects.
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