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Differential Aging of the Human Striatum: Longitudinal Evidence

Naftali Raza, Karen M. Rodriguea, Kristen M. Kennedya, Denise Headb, Faith Gunning-Dixonc and James D. Ackerd

a Institute of Gerontology and Department of Psychology, Wayne State University, Detroit MI
b Department of Psychology, Washington University, St. Louis, MO
c Department of Psychology, Long Island Jewish Medical Center, Glen Oaks, NY
d Diagnostic Imaging Center, Baptist Memorial Hospital-East, Memphis, TN



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FIG 1. An example of demarcation and tracing of three striatal regions of interest (caudate, putamen and globus pallidus) on a series of coronal images.



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FIG 2. Scatter plots for two volumetric measures of three striatal regions of interest taken on 53 subjects 5 years apart. The lines indicate linear regression of adjusted volumes on age at time 1 (solid line) and time 2 (broken line). Observations at time 1 are represented by solid circles, and observations at time 2 by empty circles. Regional volumes are adjusted for the intracranial volume.