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AJNR - American Journal of Neuroradiology

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Neurotoxicity of Intrathecal Methotrexate: MR Imaging Findings

Claudio Sandoval^a, Martin Kutscher^a, Somasundaram Jayabose^a and Michael Tenner^b

^a Department of Pediatrics, New York Medical College, Valhalla, New York
^b Department of Radiology, New York Medical College, Valhalla, New York

View larger version (129K): [in a new window]   FIG 1. At presentation, ADC maps (A, B, and C) and diffusion-weighted images (D, E, and F) showed restrictive diffusion in the frontoparietal white matter and splenium of the corpus callosum. T2-weighted fluid-attenuated inversion recovery images (G and H) are normal.

View larger version (89K): [in a new window]   FIG 2. Three weeks after presentation, the ADC maps (A, B, and C) and diffusion-weighted images (D, E, and F) have normalized. No restricted diffusion is seen in the white matter. Fluid-attenuated inversion recovery images (G and H), however, now show prolonged T2 changes in the areas of prior restricted diffusion. The postgadolinium sequences (I and J) show no enhancement.