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AJNR - American Journal of Neuroradiology

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Isolated Translocation of Wernicke’s Area to the Right Hemisphere in a 62-Year-Man with a Temporo-Parietal Glioma

Nicole M. Petrovich^a, Andrei I. Holodny^a, Cameron W. Brennan^c and Philip H. Gutin^b

^a Department of Radiology, Advanced Neuroimaging Laboratory, Memorial Sloan-Kettering Cancer Center, New York, NY
^b Department of Neurosurgery, Memorial Sloan-Kettering Cancer Center, New York, NY
^c Dana-Farber Cancer Institute, Medical Oncology, Harvard Medical School, Boston, MA

View larger version (136K): [in a new window]   FIG 1. Postcontrast left sagittal image from a 62-year-old right-handed man, showing a mostly nonenhancing temporo-parietal neoplasm involving superior temporal gyrus and portions of the supramarginal and angular gyri and underlying white matter, the expected location of Wernicke’s area.

View larger version (58K): [in a new window]   FIG 2. Axial fMRI results showing Broca’s area in the left hemisphere and activity most consistent with Wernicke’s area in the right hemisphere. The figure shows voxels at a correlation coefficient of 0.46 (P = 4.0 x 10-6) or higher. The language map is shown at this correlation coefficient, because it was the most robust representation of language activity in both hemispheres while minimizing the noise that would be seen at even lower thresholds.