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AJNR - American Journal of Neuroradiology

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Brain Tumor Classification by Proton MR Spectroscopy: Comparison of Diagnostic Accuracy at Short and Long TE

Carles Majós^a, Margarida Julià-Sapé^b, Juli Alonso^a, Marta Serrallonga^a, Carles Aguilera^a, Juan J. Acebes^c, Carles Arús^b and Jaume Gili^a

^a Institut de Diagnòstic per la Imatge, Hospital Duran i Reynals, L’Hospitalet de Llobregat, Barcelona, Spain
^b Departament de Bioquímica i Biologia Molecular, Unitat de Ciències, Universitat Autònoma de Barcelona, Barcelona, Spain
^c Department of Neurosurgery, Hospital Prínceps d’Espanya, L’Hospitalet de Llobregat, Barcelona, Spain

View larger version (27K): [in a new window]   FIG 1. Mean spectra at short TE (TE = 30) of the five tumor types included in the study.

View larger version (25K): [in a new window]   FIG 2. Mean spectra at long TE (TE = 136) of the five tumor types included in the study.

View larger version (27K): [in a new window]   FIG 3. Box plots show the distribution of some relevant resonances. The horizontal line is the median, the ends of the boxes are the upper and lower quartiles, and the vertical lines show the full range of values in the data. The extreme points (*) are outliers. A, LIP13 at short TE. B, LIP13 at long TE. C, Ala at short TE. D, Ala at long TE. E, CR at short TE. F, CR at long TE. G, CHO at short TE. H, CHO at long TE. I, Gly/MI at short TE. J, Gly/MI at long TE.

View larger version (18K): [in a new window]   FIG 4. Scatter plots show the distribution of the complete set of cases at short TE (A) and long TE (B) by using the two first discriminant functions obtained for linear discriminant analysis (x axis, value obtained with the first discriminant function; y axis, value obtained with the second discriminant function). Open circle indicates meningiomas; open square, low-grade astrocytomas; open diamond, anaplastic astrocytomas; open triangle, glioblastomas-metastases. The large black symbols show the centroid for every tumor group. With this method, new cases with unknown diagnosis are classified according to their distance to the centroids.