Advanced

AJNR - American Journal of Neuroradiology

This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Paulsen, J. S. Articles by Rao, S. M. Search for Related Content PubMed PubMed Citation Articles by Paulsen, J. S. Articles by Rao, S. M.

fMRI Biomarker of Early Neuronal Dysfunction in Presymptomatic Huntington’s Disease

Jane S. Paulsen^a, Janice L. Zimbelman^b,c, Sean C. Hinton^c, Douglas R. Langbehn^a, Catherine L. Leveroni^d, Michelle L. Benjamin^a, Norman C. Reynolds^c and Stephen M. Rao^c

^a Department of Psychiatry, University of Iowa College of Medicine, Iowa City
^b Department of Health Sciences, Carroll College, Waukesha, WI
^c Department of Neurology, Medical College of Wisconsin, Milwaukee
^d Psychology Assessment Center, Massachusetts General Hospital, Boston

View larger version (38K): [in a new window]   FIG 1. Mean percentage of correct responses and reaction times for T and P tasks for the control, far, and close groups. Asterisk indicates close < control participants (P < .05).

View larger version (25K): [in a new window]   FIG 2. Mean volumes of the left and right heads of the caudate for the control, far, and close groups. Asterisk indicates close < control participants (P < .05).

View larger version (68K): [in a new window]   FIG 3. Activation foci (P < .01) derived from the T-minus-C comparison for the control, far, and close groups. Top row, Axial sections are 6 mm superior to the anterior commissure–posterior commissure line. Bottom row, Sections represent the midsagittal plane.

View larger version (18K): [in a new window]   FIG 4. Volume of activation in the thalamus, caudate/putamen, and pre-SMA/cingulate derived from the time-minus-control subtraction for the control, far, and close groups.