Pretransplantation Conditioning Influence on the Occurrence of Cyclosporine or FK-506 Neurotoxicity in Allogeneic Bone Marrow Transplantation
Walter S. Bartynskia,
Zella R. Zeiglerb,
Richard K. Shadduckb and
John Listerb
a Department of Radiology, The Western Pennsylvania Hospital, Pittsburgh
b Department of Medicine, The Western Pennsylvania Hospital, Pittsburgh
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FIG 1. Images in a 40-year-old woman with non-Hodgkin lymphoma who presented 27 days after allo-BMT with a seizure. Conditioning regimen was BEAM therapy. Blood pressure was 114/64 mm Hg and FK-506 level at the time of toxicity was 12.7 ìg/L (normal range, 5–20 ìg/l).
A–D, FLAIR images demonstrate abnormal signal intensity in the cortex and subcortical white matter of the left inferior temporal-occipital junction (arrowhead in A), occipital poles (large arrows in A), parietal region (short arrows in B and C), and frontal lobes (long arrows in C and D) bilaterally, typical of cyclosporine or FK-506 neurotoxicity. The brain lesions in this patient are somewhat confluent and demarcate the junction between lateral cerebral hemispheric branches from the middle cerebral artery and medial hemispheric supply from the anterior and posterior cerebral arteries.
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