Early Prenatal MR Imaging Diagnosis of Polymicrogyria
Andrea Righinia,
Salvatore Zirpolic,
Federica Mrakicc,
Cecilia Parazzinia,
Laura Poglianib and
Fabio Triulzia
a Department of Radiology and Neuroradiology, Istituti Clinici di Perfezionamento, Milan, Italy
b Department of Neonatology, Istituti Clinici di Perfezionamento, Milan, Italy
c Institute of Radiology, University of Milan, Milan, Italy
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FIG 1. Multiplanar T2-weighted single-shot fast spin-echo sections from 24-week (A–C) and 34-week (D–G) gestational age.
A, Coronal section showing absent septum pellucidum and focal irregular wartlike profile of the cortical rim in the left hemisphere (white arrow).
B, Contiguous coronal section depicting a small hypointense subependymal nodule associated with a thin hypointense line extending toward the cortex (white arrowhead).
C, Axial section showing an unclear area of cortical-rim abnormal profile with apparent irregular infolding in the left hemisphere (curved white arrow).
D, Axial section depicting the absence of septum pellucidum.
E (left) and F (right), Axial contiguous sections from the same study showing in the left posterior frontal lobe a focal area of abnormal cortical-rim profile with some irregular infolding (black arrow).
G, Coronal section from the same study depicting in the left frontal lobe the same area of irregular and abnormally tight cortical gyri infolding (curved white arrow). Only the left half of the section has been reproduced, to eliminate the dynamic windowing problems related to the high signal intensity in the right side of the image, caused by the proximity to the surface coil.
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FIG 2. Three T2-weighted coronal FSE sections from the postnatal MR imaging study. A focal area of abnormally tight cortical infolding at the left frontal lobe cortex level is visible (white arrows). A much less extensive and unclear area of similar focal cortical alteration is visible also contralaterally (white arrowheads). In the subependymal region underneath the left frontal cortex abnormality, a nodule of heterotopic gray matter is clearly visible (black arrow). The septum pellucidum is absent.
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