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AJNR - American Journal of Neuroradiology

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Increased Anterior Temporal Lobe T2 Times in Cases of Hippocampal Sclerosis: A Multi-Echo T2 Relaxometry Study At 3 T

Regula S. Briellmann^a,b, Ari Syngeniotis^a, Steve Fleming^a, Renate M. Kalnins^b,c, David F. Abbott^a and Graeme D. Jackson^a,b

^a Brain Research Institute, Austin Health, Victoria, Australia
^b University of Melbourne, Austin Health, Victoria, Australia
^c Department of Anatomical Pathology, Austin Health, Victoria, Australia

View larger version (50K): [in a new window]   FIG 1. Left, Coronal view T2-weighted image of a control volunteer, obtained at the level of the body of the hippocampus. Region of interest is positioned in the left hippocampus. Right, Display of the relaxation curve and the calculated theoretical exponential curve. The relaxation curve of the tissue very closely matched the calculated theoretical exponential curve. T2 relaxation time measured by using both acquisition and measurement techniques correlated very closely.

View larger version (10K): [in a new window]   FIG 2. Distribution of the ipsilateral hippocampal T2 values for control volunteers, patients with focal cortical dysplasia, and patients with hippocampal sclerosis. Note the marked signal intensity increase for all patients with hippocampal sclerosis.