Advanced

AJNR - American Journal of Neuroradiology

This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Govindaraju, V. Articles by Maudsley, A. A. Search for Related Content PubMed PubMed Citation Articles by Govindaraju, V. Articles by Maudsley, A. A.

Volumetric Proton Spectroscopic Imaging of Mild Traumatic Brain Injury

Varanavasi Govindaraju^a, Grant E. Gauger^c, Geoffrey T. Manley^c, Andreas Ebel^a, Michele Meeker^c and Andrew A. Maudsley^b

^a Northern California Institute for Research and Education, MR spectroscopy Unit, Veterans Affairs Medical Center
^b Department of Radiology, University of California, San Francisco
^c Department of Neurologic Surgery, University of California, San Francisco

View larger version (172K): [in a new window]   FIG 1. Sections for data analysis and corresponding MRSI sections. Central five sections (numbered 3–7) selected for data analysis in the 140-mm-thick slab over which the MRSI acquisition was carried out.

View larger version (124K): [in a new window]   FIG 2. A–F, MR images corresponding to the full thickness of each MRSI section (C and D are the same), with overlays indicating the 25 regions used for data analysis.

View larger version (31K): [in a new window]   FIG 3. Mean regional NAA/Cho ratios of control (black) and TBI (gray) subjects. Numbers above each histogram pair refer to regions identified in Figure 2; multiple numbers indicate that data from the regions were grouped. Average SD for control and TBI subjects were 16.7% and 16.3%, respectively.

View larger version (14K): [in a new window]   FIG 4. Mean global metabolite ratios in subjects with TBI (open symbols) plotted against GCS score at admission. Horizontal lines and solid symbols indicate ratios for controls, and error bars show 2 SD. Triangles, circles, and diamonds indicate NAA/Cho, NAA/Cr, and Cho/Cr ratios, respectively.

View larger version (16K): [in a new window]   FIG 5. Mean global metabolite ratios in TBI subjects obtained shortly after injury plotted against GOS scores at discharge (open symbols) and at 6 months after injury (solid symbols). Data are separated according to moderate (M) and good (G) outcomes. NAA/Cr (circles), Cho/Cr (diamonds), and NAA/Cho (triangles) ratios are indicated. Horizontal lines indicate ratios for controls, and error bars show 2 SD.