Susceptibility-Based Imaging of Glioblastoma Microvascularity at 8 T: Correlation of MR Imaging and Postmortem Pathology
Gregory A. Christoforidisa,
Allahyar Kangarlua,
Amir M. Abduljalila,
Petra Schmalbrocka,
Abhik Chaudhrya,b,
Alan Yatesb and
Donald W. Chakeresa
a Department of Radiology, the Ohio State University Medical Center, Columbus
b Department of Pathology, the Ohio State University Medical Center, Columbus
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FIG 1. Images from the intact cadaver of a patient with known GBM.
A, Axial 8-T GE MR image (matrix = 1024 x 1024;TR/TE = 600/12; flip angle = 20°) in the patient with GBM at the level of the trigone of the lateral ventricles (T) and the level of the splenium (S) demonstrates an exophytic mass extending into the left lateral ventricle. A = anterior, P = posterior.
B–D, Reticulin-stained sections (original magnification x100) correspond to an area of normal gray matter (B), the focus depicted by the arrow in A (C), and the focus depicted by the arrowhead in A (D). The arrow in B depicts the sulcus. Image in C shows an area of high vascular density and large vessels. Image in D corresponds to an area of vascularity and vessel size similar to that of the gray matter in the tumor bed. Vessels are depicted by arrows in C and D.
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FIG 2. Additional images from the intact cadaver of a patient with known GBM.
A, Axial 8-T GE MR image (matrix = 1024 x 1024;TR/TE = 600/12; flip angle = 20°) in the patient with known GBM involving the splenium of the corpus callosum. This is 2 mm superior to the image in Figure 1A. Numerous small vessels are visible in the tumor bed. A = anterior, P = posterior.
B and C, Hematoxylin-eosin-stained sections (original magnification x200) to the foci depicted by the arrow in A (B) and the arrowhead in A (C). B, Histologic specimen shows larger vessels (arrow) in dense concentration. Vessels in this region of exophytic tumor are also severely deformed in A, with loss of normal organization. Vessels can be seen crossing from the corpus callosum into the tumor. C, Image shows tumor infiltration with vascular density similar to white matter.
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