Degenerative Thalamic Hamartoma: CT and MR Imaging Features
Tomoki Kanekoa,
Rei Kawakamia,
Yasunari Fujinagaa,
Kazuhiro Oguchib,
Jun Nakayamac,
Kazuhiro Hongoc and
Masumi Kadoyaa
a Department of Radiology, Shinshu University School of Medicine, Matsumoto, Japan
b Department of Pathology, Shinshu University School of Medicine, Matsumoto, Japan
c Department of Neurosurgery, Shinshu University School of Medicine, Matsumoto, Japan
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FIG 1. Noncontrast CT scan shows a low-attenuation mass in the right thalamus. Marked calcifications are seen in the center of the mass lesion (arrow).
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FIG 2. Axial MR images. All images are obtained at same level.
A, T1-weighted image (500/20 [TR/TE]). B, T2-weighted image (5000/88 [TR/TE]). C, T1-weighted (500/20 [TR/TE]) image after gadolinium-DTPA administration.
The mass lesion shows lower signal intensity on the T1-weighted image (A) and higher signal intensity on the T2-weighted MR image (B) relative to gray matter. Calcified regions show slightly greater signal intensity on the T1-weighted image (A) and are enhanced after administration of gadolinium-DTPA (C, light arrows). CSF-like signal intensity exists in the core of the lesion (dark arrows).
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FIG 3. A, Coronal image after administration of gadolinium-DTPA (500/20 [TR/TE]). B, Sagittal T2-weighted image (4000/88.9 [TR/TE]). The margin of the mass lesion is covered with thalamus extending in a beaklike shape (arrows).
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FIG 4. A, Hematoxylin and eosin stain (magnification x100). B, N-CAM stain (magnification x200). C, Polysialic acid stain (magnification x200).
Proliferation of vessels and minute calcified corpuscles (dark arrows) are observed. There are no atypical cells or abnormal division of nucleus. Immunohistochemical staining is positive for N-CAM (dark arrows) and negative for polysialic acid.
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