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AJNR - American Journal of Neuroradiology

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Influenza-Associated Encephalitis/Encephalopathy with a Reversible Lesion in the Splenium of the Corpus Callosum: A Case Report and Literature Review

Jun-ichi Takanashi^a, A. James Barkovich^b, Ken-ichi Yamaguchi^a and Yoichi Kohno^a

^a Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan
^b Neuroradiology Section, Department of Radiology, University of California, San Francisco, San Francisco, CA

View larger version (95K): [in a new window]   FIG 1. Case 1. On day 4, fast spin-echo image (A: TR/TE = 4000/100), DWI (B: spin-echo EPI; TR = 5000; b = 1000), and ADC map (C: ADC = 0.485 x 10–3 mm2/s) show a lesion in the central splenium of the corpus callosum. This lesion had resolved on a fast spin-echo image, DWI (D), and ADC map obtained on day 10.

View larger version (103K): [in a new window]   FIG 2. Case 2. Fluid-attenuated inversion recovery (A), DWI (B and C), and ADC map (D and E: ADC of SCC = 0.325 x 10–3 mm2/s) show a lesion in the central splenium and symmetric lesions in the centrum semiovale adjacent to the deep central sulci on day 5. Follow-up fluid-attenuated inversion recovery, DWI (F and G), and ADC maps obtained on day 10 did not show the lesion.