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AJNR - American Journal of Neuroradiology

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MR Imaging in the Diagnosis of Desmoplastic Infantile Tumor: Retrospective Study of Six Cases

Guillaume Trehan^a, Helene Bruge^a, Matthieu Vinchon^b, Chadi Khalil^a, Marie M. Ruchoux^c, Patrick Dhellemmes^b and Gustavo Soto Ares^a

^a Department of Neuroradiology, Hopital Roger Salengro, Centre Hospitalier Regional Universitaire de Lille, Lille, France
^b Department of Neurosurgery, Hopital Roger Salengro, Centre Hospitalier Regional Universitaire de Lille, Lille, France
^C Department of Pathology, Hopital Roger Salengro, Centre Hospitalier Regional Universitaire de Lille, Lille, France

View larger version (55K): [in a new window]   FIG 1. Case 1. Axial T1- (A), axial T2- (B), and axial postgadolinium T1-weighted (C) MR images show a large supratentorial and heterogeneous tumor involving the frontotemporoparietal lobes with a major mass effect. The solid part of the tumor has two components. The peripheral part is heterogeneous and moderately hyperintense on T1-weighted images and shows low signal intensity on T2-weighted images suggestive of intratumoral bleeding; the medial part is enhanced after gadolinium injection. The posterior cystic part of the lesion is of high signal intensity on T1- and T2-weighted images, which is compatible with a recent bleeding episode. Radiologic appearance is suggestive of a malignant lesion.

View larger version (61K): [in a new window]   FIG 2. Case 3. Axial postgadolinium T1- (A), coronal postgadolinium T1- (B), and axial T2-weighted (C) MR images show a typically large supratentorial mass with a peripheral solid and a deep cystic component. The peripheral solid component is enhanced after gadolinium injection (A and B) and is associated with a meningeal thickening and enhancement. Note the major mass effect on the midline and the ventricles.

View larger version (91K): [in a new window]   FIG 3. Standard hematoxylin coloration (magnification x250) shows the fusiform astrocytic cells forming a dense fascicle pattern.

View larger version (91K): [in a new window]   FIG 4. DIG with marked neurofilament immunostain (magnification x400) due to the presence of neural cells (black arrow).