Differences in Regional Cerebral Blood Flow Patterns in Male versus Female Patients with Alzheimer Disease
Haruo Hanyua,
Soichiro Shimizua,
Yuriko Tanakaa,
Masaru Takasakia,
Kiyoshi Koizumib and
Kimihiko Abeb
a Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
b Department of Radiology, Tokyo Medical University, Tokyo, Japan
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FIG 1. Statistical maps showing the relative decrease of rCBF in men with AD compared with that in control subjects (top) and in women with AD compared with that in control subjects (bottom).
Although both patient groups show a notable decrease of rCBF in the parietotemporal lobes, posterior cingulate cortex, cinguloparietal transitional area, and frontal association cortices, men have a more severe reduction of rCBF in the parietal lobe and posterior cingulate cortex, and women have reduced rCBF in additional areas, including the frontal lobe and medial temporal regions. The color of the outer contour corresponds to a Z score of 7.
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FIG 2. Statistical maps showing the relative decrease of rCBF in men with AD compared with that in women with AD (top) and in women with AD compared with that in men with AD (bottom).
Men have a more severe decrease of rCBF in the parietooccipital and medial parietal lobes, whereas women have a more severe decrease of rCBF in the lateral, medial and orbital frontal lobes, and medial and inferior temporal regions. The color of the outer contour corresponds to a Z score of 7.
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