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AJNR - American Journal of Neuroradiology

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A New Method for Analyzing Histograms of Brain Magnetization Transfer Ratios: Comparison with Existing Techniques

Liang Qiang Zhou^a, Yue Min Zhu^a, Jérôme Grimaud^a,c, Marc Hermier^a,b, Marco Rovaris^d and Massimo Filippi^d

^a CREATIS, CNRS UMR 5515 and INSERM 4630, Chartres, France
^b Hospital of Neurology of Lyon, Chartres, France
^c Hospital Louis Pasteur, Chartres, France
^d Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University H San Raffaele, Milan, Italy

View larger version (32K): [in a new window]   FIG 1. Graphical representation of the MTR histogram–derived parameters used in this study.

View larger version (10K): [in a new window]   FIG 2. Average MTR histograms from 10 patients with MS (dotted line) and 10 healthy control subjects (solid line) obtained by using the same MR imaging unit.

View larger version (10K): [in a new window]   FIG 3. Average MTR histograms from groups B (solid line) and C (dotted line), the two control groups, who were imaged with different MR imaging units.

View larger version (14K): [in a new window]   FIG 4. Scatterplot of MTR histogram peak heights indicates the value that best distinguished patients with MS and the control group B.

View larger version (14K): [in a new window]   FIG 5. Scatterplot of MTR25 values indicates the value that best distinguished patients from the control group B.

View larger version (14K): [in a new window]   FIG 6. Scatterplot of AMTR2/3 values indicates that AMTR2/3 was the best parameter for differentiating patients from control subjects.