Diffusion Tensor Images in Children with Early-Treated, Chronic, Malignant Phenylketonuric: Correlation with Intelligence Assessment
Steven Shinn-Forng Penga,
Wen-Yih Isaac Tsenga,
Yin-Hsiu Chienb,
Wuh-Liang Hwuc and
Hon-Man Liua
a Departments of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei
b Departments of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei
c Departments of Medical Genetics
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FIG 1. Control subject aged 27 months. Maps of the brain at the level of the lateral ventricular bodies show the right parietal-occipital central white matter with ROIs in the frontoparietal, parietal-occipital, frontal central white matter and in the anterior and posterior corpus callosum.
A, EV1; B, EV2; C, EV3; D, trace ADC.; E, FA index.
F, Color-coded fiber orientation. Left-right, anterior-posterior, and superior-inferior directions are associated with pure red, green, and blue, respectively. Combinations of these colors represent oblique fibers.
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FIG 2. PKU patient aged 25 months. Cerebral maps at the level of lateral ventricular bodies.
A, EV1.
B, EV2 increases in the bilateral frontal and parietal-occipital central parenchyma, more prominently in the right parietal-occipital central areas (arrows). High-EV2 area is more extensive in bilateral parietal-occipital central areas than in areas shown in Figure 1B.
C, High EV3 is prominent in parietal-occipital central areas, more on the right (arrows) than the left.
D, ADCs are diffusely increased, slightly in the bilateral frontal, right frontoparietal, and bilateral parietal-occipital central parenchyma (arrows); the difference is not significant.
E, FA is reduced in parietal-occipital central white matter, more on the right (arrows) than the left.
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