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Abnormal Hippocampal Development in Children with Medulloblastoma Treated with Risk-Adapted Irradiation

Bonnie J. Nagela,g, Shawna L. Palmera, Wilburn E. Reddickb,f, John O. Glassb, Kathleen J. Heltonb, Shengjie Wuc, Xiaoping Xiongc, Larry E. Kunb, Amar Gajjard,e and Raymond K. Mulherna,e

a Division of Behavioral Medicine, St Jude Children’s Research Hospital, Memphis
b Departments of Radiological Sciences, St Jude Children’s Research Hospital, Memphis
c Departments of Biostatistics and Epidemiology, St Jude Children’s Research Hospital, Memphis
d Departments of Hematology/Oncology, St Jude Children’s Research Hospital, Memphis
e Department of Pediatrics, University of Tennessee College of Medicine, Memphis
f Department of Electrical, Computer, and Biomedical Engineering, University of Memphis, TN
g Department of Psychiatry, University of California San Diego School of Medicine



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  		FIG 1. Individual patients’ and predicted left hippocampal volumes over time since diagnosis (DX).



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  		FIG 2. Individual patients’ and predicted right hippocampal volumes over time since diagnosis (DX).



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  		FIG 3. T1-weighted MR image represents the midsagittal orientation of a dosimetry map for a high-risk patient. Small dose-map area (white outlined posterior fossa area) receives the highest total CSI dose (up to 60Gy).





Copyright © 2009 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X