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AJNR - American Journal of Neuroradiology

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Local Tissue Damage Assessed with Statistical Mapping Analysis of Brain Magnetization Transfer Ratio: Relationship with Functional Status of Patients in the Earliest Stage of Multiple Sclerosis

Jean-Philippe Ranjeva^a, Bertrand Audoin^a,b, My Van Au Duong^a, Danielle Ibarrola^a, Sylviane Confort-Gouny^a, Irina Malikova^a,b, Elisabeth Soulier^a, Patrick Viout^a, André Ali-Chérif^b, Jean Pelletier^a,b and Patrick Cozzone^a

^a Centre de Résonance Magnétique Biologique et Médicale, UMR Centre National de la Recherche Scientifique, No. 6612, Faculté de Médecine, Marseille, France
^b Service de Neurologie, Centre Hospitalo-Universitaire Timone, Marseille, France

View larger version (50K): [in a new window]   FIG 1. Statistical mapping analysis. Patterns of significant MTR abnormalities are observed inside the corpus callosum, bilateral occipitofrontal fascicles, right fornix, right parietal white matter, external capsule, right SLF, right ILF, optica radiata, parietal white matter, right cingulum, bilateral thalamus, bilateral caudate, right insula, and the left BA8. A, Multiplanar images of MTR decrease observed in patients with CISSMS compared with control subjects. B, Transverse images of MTR decrease observed in patients with CISSMS compared with control subjects.

View larger version (85K): [in a new window]   FIG 2. In patients with CISSMS, significant correlations between MTR and TMTA scores (Spearman rank test, P < .05) are observed inside the bilateral BA4, bilateral BA3, right BA6, left BA8, left frontal white matter, left occipitofrontal fascicles (top row, left to right) and in the left frontal white matter, left occipitofrontal fascicles, body of corpus callosum, bilateral cingulum, bilateral BA40, right lateral sulcus, and right claustrum (bottom row, left to right).

View larger version (76K): [in a new window]   FIG 3. In patients with CISSMS, significant correlations between MTR and MSFC scores (Spearman rank test, P < .05) are observed inside right SLF (FLS), right frontal white matter (WM), projections of the anterior corpus callosum (CC), splenium, and left BA40 (left to right).

View larger version (64K): [in a new window]   FIG 4. In patients with CISSMS, significant correlations between MTR and PASAT scores (Spearman rank test, P < .05) are observed in the splenium, left BA40, right BA 4, and right SLF.