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AJNR - American Journal of Neuroradiology

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MR Quantitation of Volume and Diffusion Changes in the Developing Brain

Lijuan Zhang^a, Kathleen M. Thomas^b, Matthew C. Davidson^b, B. J. Casey^b, Linda A. Heier^a and Aziz M. Ulu^a,b

^a Department of Radiology, Weill Medical College of Cornell University, New York, NY
^b Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, NY

View larger version (20K): [in a new window]   FIG 1. Representative diffusion distribution histogram in a 3.5-year-old girl with triple gaussian fit. BDav = 0.839 10–5cm2/s, = 0.183 10–5cm2/s.

View larger version (73K): [in a new window]   FIG 2. Locations of ROIs in a 2-year-old boy. Round ROIs were placed on Dav maps to measure the diffusion constants of the PVWM, caudate, thalamus, and genu and splenium of the corpus callosum in all subjects.

View larger version (14K): [in a new window]   FIG 3. Biexponential curves of Dav versus age. A, Caudate and splenium of the corpus callosum. B, Thalamus, PVWM, and whole brain (BDav). C, Data for the genu are fitted by using a single exponential curve. Brain diffusion decreases fastest in the first 2 years, with slower changes afterward.

View larger version (19K): [in a new window]   FIG 4. Age dependence of brain volume. The most significant volume changes occur within the first 2 postnatal years. Lines are the logarithmic fit.

View larger version (19K): [in a new window]   FIG 5. ICV measured by using the pixel count and the brain model. Correlation was excellent (R = 0.999).