MR Imaging of a Posterior Mediastinal Ganglioneuroma: Fat as a Useful Diagnostic Sign
Sheila Duffya,
Miral Jhaverib,
Jennifer Scudierrec,
Elizabeth Cochranc and
Michael Huckmanb
a Department of Neurology, Rush University Medical Center, Chicago, IL
b Department of Radiology, Rush University Medical Center, Chicago, IL
c Department of Pathology, Rush University Medical Center, Chicago, IL
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FIG 1. A–C, Sagittal T1-weighted images (TR 366/TE 14), from right to left, showing a right paraspinal mass with predominant high T1 signal intensity and interspersed areas of intermediate signal intensity. The mass extends through the intervertebral foramina, causing widening of the foramina.
D, Axial T1-weighted image (TR 366/TE 14) showing a right paraspinal mass that extends through the intervertebral foramina causing widening of the foramina and scalloping of the posterior margin of the vertebral body.
E, Axial T2-weighted fast spin-echo image (TR 3400/TE 110) showing mild effacement of the right lateral aspect of the thecal sac without any significant compression.
F and G, Sagittal fat-suppressed postcontrast T1-weighted images (TR 366/TE 14) show that the mass follows the signal intensity of the subcutaneous fat. There are interspersed areas of enhancement.
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FIG 2. A, Microscopic picture demonstrating adipose tissue (short arrow), Schwann cells, lymphocytes (arrowhead), and ganglion cells (long arrow); original magnification 10x.
B, On the left, S100 immunostain demonstrates that the tissue is composed predominantly of Schwann cells. On the right, Synaptophysin immunostain confirms the presence of ganglion cells (arrows); original magnification 20x.
C, High-power picture of multinucleated ganglion cells (arrows); original magnification 40x.
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