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AJNR - American Journal of Neuroradiology

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Qualitative Assessment of Brain Anomalies in Adolescents with Mental Retardation

Michael D. Spencer^a, Rod J. Gibson^b, T. William J. Moorhead^a, Peter M. Keston^b, Peter Hoare^a, Jonathan J.K. Best^b, Stephen M. Lawrie^a and Eve C. Johnstone^a

^a Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, United Kingdom
^b Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom

View larger version (69K): [in a new window]   FIG 1. Examples of absent (A), moderate (B), and marked (C) thinning of the corpus callosum on midsaggital MR images.

View larger version (72K): [in a new window]   FIG 2. Examples of absent (A), moderate (B), and marked (C) enlargement of the frontal horns of the lateral ventricles. These images also show absent (A), moderate (B), and marked (C) blunting of the lateral angles of the frontal horns of the lateral ventricles.

View larger version (17K): [in a new window]   FIG 3. Scatterplot of total abnormality score against IQ for all 120 subjects. There is a significant negative correlation for total abnormality score versus IQ (r = –0.320; P < .001).