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AJNR - American Journal of Neuroradiology

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Regional Brain Atrophy Evolves Differently in Patients with Multiple Sclerosis According to Clinical Phenotype

Elisabetta Pagani^a,b, Maria A. Rocca^a,b, Antonio Gallo^a, Marco Rovaris^a,b, Vittorio Martinelli^b, Giancarlo Comi^b and Massimo Filippi^a,b

^a Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
^b Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy

View larger version (68K): [in a new window]   FIG 1. Color-coded areas (SPMt) of brain atrophy development in RRMS overlaid on a template T1-weighted image. All sections show extensive involvement of the ventricular system. Images A and B show involvement of the pericerebellar spaces and cerebellar tentorium. Images A, C, and D show involvement of the putamen; corpus callosum; insula; cingulate sulcus; and frontal, parietal, temporal, and occipital cortex.

View larger version (48K): [in a new window]   FIG 2. Color-coded areas (SPMt) of brain atrophy development in SPMS overlaid on a template T1-weighted image. Image A shows the involvement of the bilateral anterior orbital gyrus and left mammillary body. B shows the involvement of the caudate nuclei; left middle temporal gyrus; left thalamus; and frontal, parietal, temporal and occipital region. C shows the involvement of the cingulate sulcus and regions of frontal and parietal cortex.

View larger version (48K): [in a new window]   FIG 3. Color-coded areas (SPMt) of brain atrophy development in PPMS overlaid on a template T1-weighted image. A shows the involvement of the left middle occipital gyrus, bilateral parahippocampal gyri, and bilateral prepontine and quadrigeminal cisterns. B shows the involvement of the head of the left caudate nucleus, insula, and bilateral middle temporal gyrus. C shows the involvement of the bilateral central sulci (precentral and postcentral gyri) and regions of frontal and parietal cortex.